12/9/2023 0 Comments Novartis sentinel spectrumThis is the case for Collies and related breeds, which have a mutation in the MDR-1 gene that affects the blood-brain barrier and makes it more permeable to such compounds than in dogs without this mutation. Consequently dosing must be as accurate as possible. They can suffer more or less serious adverse effects if treated at dose rates slightly higher than the recommended ones. emodepside) that can cross the blood-brain barrier. Dogs of some breeds do not tolerate macrocyclic lactones or other medicines (e.g. Learn more about tablets and their safety. Never use on small dogs tablets approved for large dogs. WARNING !!!: Never use on cats tablets approved only for dogs. Suspected poisoning? Read the article on lufenuron safety, milbemycin oxime safety and/or praziquantel safety in this site. Estimated Hazard Class according to the WHO : not applicable for veterinary medicines.For lufenuron >2000 mg/kg for milbemycin oxime 980 mg/kg for praziquantel 2000 to 3000 mg/kg ≈ > 45 kg bw: administer appropriate combination of tablets ≈ 22.8 to 45 kg bw: 1 tablet with 460 mg lufenuron, 23 mg milbemycin oxime and 228 mg praziquantel (equivalent to 20.2 - 10.2 mg/kg lufenuron and 1.0 to 0.5 mg/kg milbemycin oxime and 10.0 to 5.0 mg/kg praziquantel) ≈ 11.4 to 22.7 kg bw: 1 tablet with 230 mg lufenuron, 11.5 mg milbemycin oxime and 114 mg praziquantel (equivalent to 20.2 - 10.1 mg/kg lufenuron and 1.0 to 0.5 mg/kg milbemycin oxime and 10.0 to 5.0 mg/kg praziquantel) ≈ 3.9 to 11.3 kg bw: 1 tablet with 115 mg lufenuron, 5.75 mg milbemycin oxime and 57 mg praziquantel(equivalent to 29.5 - 10.2 mg/kg lufenuron, 1.5 to 0.5 mg/kg milbemycin oxime and 14.6 to 5.0 mg/kg praziquantel) ≈ 1 to 3.8 kgbw: 1 tablet with 46 mg lufenuron, 2.3 mg milbemycin oxime and 22.8 mg praziquantel (equivalent to 46 to 12.1 mg/kg lufenuron, 2.3 to 0.6 mg/kg milbemycin oxime and 22.8 to 6.0 mg/kg praziquantel) * Can be slightly different in some countries: read the product label! PARASITES CONTROLLED* (spectrum of activity): Fleas, heartworms ( Dirofilaria immitis) and other roundworms ( Toxascaris leonina, Toxocara canis, Ancylostoma caninum, Trichuris vulpis), tapeworms ( Dipylidium caninum, Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis)
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